High shear mixer granulator for wet granulation of pharmaceutical powders
Wet granulation requires precise control over mixing intensity, binder distribution, and particle growth to achieve consistent granule density and reproducible downstream processing.
Achieve rapid and uniform wet granulation with controlled mixing and shear
The Gansons High Shear Mixer Granulator is designed for fast and controlled wet granulation of pharmaceutical powders, combining high-intensity mixing with precise binder distribution and granule formation. The system enables solid-solid and solid-liquid processing within a single vessel, producing dense and uniform granules for tablet formulation.
The process is driven by a proprietary impeller and chopper configuration that creates strong vortex movement and efficient powder recirculation. This ensures homogeneous mixing across varying bulk densities while promoting rapid granule growth and consistent particle size distribution.
The chopper supports both binder distribution and deagglomeration, preventing oversized agglomerates and improving granule uniformity. The optimized process bowl geometry eliminates dead zones and enhances material flow into the shear zone, ensuring repeatable processing results.
Integrated automation monitors parameters such as torque, power, and time to enable accurate end-point detection and reproducible batch performance. The system supports recipe-driven operation and complies with regulatory requirements for data integrity and process control.
The equipment is designed for safe pharmaceutical production with features such as wash-in-place cleaning, sealed shaft systems to prevent contamination, and optional ATEX-compliant designs. Available in capacities ranging from laboratory to large-scale production, the system supports scalable process development and manufacturing.
Benefits
- — Rapid and uniform wet granulation with controlled shear
- — Contained and cleanable design for pharmaceutical use
- — Consistent granule density and particle size distribution
- — Scalable from R&D to production volumes
- — Accurate end-point detection for reproducible batches